|
KMID : 1149220080160010131
|
|
Korean Journal of Oriental Medical Prescription
2008 Volume.16 No. 1 p.131 ~ p.145
|
|
|
A Comparative Study for Effects of Chongmyungtang and Chocolate Mixed Chongmyungtang on Learning and Memory Impairment
|
|
Park Won-Sang
Choi Hyun
Kim Bum-Hoi
Shin Jung-Won
Sohn Young-Joo
Sohn Nak-Won
Jung Hyuk-Sang
|
|
|
Abstract
|
|
|
|
With tablets and powder, decoction has been a widely-used method of medicine formula. However, for these formulas have unique bitter tastes and flavors of herbal component materials as it is, the compliance of herbal medicine is severly decreased especially for female and younger patients. Consequently, expected treatment effects can’t be acquired completely. If loathsome tastes and flavors of decoction were effectively reduced while pharmacological activity were kept intact, the compliance could be promoted Chong-Myung-Tang has been widely prescribed for student patients with memory This study shows that Chong-Myung-Tang+chocolate have no difference from Chong-Myung-Tang in terms of pharmacological activity. Sensory difference with net chocolate was also surved. In order to observe the difference of Chong-Myung-Tang+chocolate and Chong-Myung-Tang, memory impairment was induced by intraventricular injection of Aβ25-35 peptides on mice and Chong-Myung-Tang and Chong-Myung-Tang+chocolate were administered orally for 14 days. In water maze task, improvement of learning ability during acquisition period and significant increase of memory score during retention period resulted from the treatment of Chong-Myung-Tang and Chong-Myung-Tang+chocolate with respect to the Aβ-injected control animals. Furthermore, the Aβ25-35 toxicity on the hippocampus was assessed with immunohistochemistry (Bax, TUNEL), and differences in antioxidant activity was observed through TBARS and DPPH test. We employed sensory tests using chocolate flavor, herb flavor, and bitter taste & hardness as standards to show sensory differences with net chocolate. In this study, it is demonstrated that Chong-Myung-Tang+chocolate do not disturb the pharmacological activity of Chong-Myung-Tang, and have no sensory difference with net chocolate. Chong-Myung-Tang+chocolate can be used to enhance the compliance remarkably and thought of as an effective, functional formula to maximize expected treatment.
|
|
|
KEYWORD
|
|
|
Chong-Myung-Tang, Chong-Myung-Tang+chocolate Aβ25-35, learning and memory, Bax, TUNEL, TBARS, DPPH
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|